What is a common side effect of NSAIDs?

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used medications known for their effectiveness in reducing pain, inflammation, and fever. A common side effect associated with NSAIDs is gastrointestinal (GI) disturbances. This can manifest as symptoms such as stomach pain, heartburn, nausea, or even more serious conditions like gastrointestinal bleeding and ulcer formation. The mechanism behind these GI side effects is primarily related to the inhibition of prostaglandins, which play a protective role in the stomach lining. When NSAIDs block the production of these protective prostaglandins, the stomach becomes more susceptible to acid irritation, leading to various GI issues.

While headaches, skin rash, and muscle cramps can occur as side effects of various medications, they are not as directly associated with NSAIDs as GI disturbances are. Understanding this common side effect is critical for both healthcare providers and patients to manage and mitigate risks when using these medications.