Prolonged deficiency of which vitamin can lead to night blindness?

Prolonged deficiency of Vitamin A can lead to night blindness due to its crucial role in the formation of rhodopsin, a protein in the eyes that allows for vision in low light conditions. Vitamin A is integral in maintaining proper eye health and works by supporting the function of retinal cells. When there is an insufficient amount of this vitamin, the body's ability to produce rhodopsin diminishes, impairing the vision in dim light, which is characteristic of night blindness.

In contrast, the other vitamins listed do not have a direct relation to night vision. Vitamin B is important for overall metabolic processes, while Vitamin C plays a key role in the antioxidant defense and collagen synthesis. Vitamin D is essential for bone health and calcium metabolism. None of these vitamins are as directly involved in the visual processes linked to night vision as Vitamin A.